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If you are new to the world of injectable skincare or mesotherapy, it may sound scary or intimidating. Some people unfairly compare intradermal cosmetics to aesthetic surgery, but this is like comparing a simple injection to a surgical operation. So, let’s make this point very clear: mesotherapy is nothing even close to surgery.

Our skin is a remarkable organ that does an excellent shielding job protecting us from the outside world. This is why when we need a potent effect, we need to go beneath it. In the case of mesotherapy, the needle won’t even go through the entire skin, but only the uppermost layer, or epidermis. This allows it to release the ingredients into the dermis, where they will provide the maximum beneficial effects.

Nowadays, injectable hyaluronic acid is the most used intradermal ingredient for skin rejuvenation. In this article, we are going to explore why intradermal hyaluronic acid is so popular and how to make the best of it.


HA has been the most-loved active ingredient in the fields of skincare and aesthetic medicine for over a decade, and it is likely to remain at the top for another decade or more. But why? The answer is simple—It works wonders on your skin and is 100% safe.

As you probably already know, Hyaluronic Acid is an essential skin component with incredibly potent water-retaining capabilities. It plays a vital role in keeping your skin moisturized and contributes significantly to the formation of other key skin components, such as collagen and elastin. Keeping your skin tissues well-moisturized promotes the optimal functioning of the skin as a whole, resulting in better skin quality and enhanced protection against external stressors.

Unfortunately, like other essential skin components, hyaluronic acid levels decrease with age. Therefore, incorporating hyaluronic acid or hyaluronic acid boosters into your skin routine is always a smart choice.


Hyaluronic acid can be used in several ways: topically in your daily skin regimen, ingested in oral supplements, or through intradermal injections.

Of these three options, we recommend the third—injectable hyaluronic acid. Here is why:

Hyaluronic Acid is a large molecule that cannot penetrate the skin effectively when applied topically. Therefore, while its effects are noticeable when applied this way, they are only superficial and not long-lasting. Ingested hyaluronic acid may increase HA levels throughout your body, offering beneficial effects, but it is not exclusively focused on your skin.

On the other hand, injectable hyaluronic acid acts directly within the skin, providing a highly moisturizing effect that remarkably improves the skin quality and appearance for months. 


There are two main types of injectable hyaluronic acid: crosslinked and non-crosslinked.


Crosslinked HA has undergone a process that links the HA molecules together, forming a moldable gel. It is primarily used for fillers. Depending on the level of crosslinking, HA fillers have different densities and can address different concerns. Low-density HA is typically used to correct fine lines and superficial wrinkles, while high-density HA is more compact and can fill up deep wrinkles and folds, restore or reshape facial volumes, enhance lips or cheeks, and more. It can restore a youthful appearance by targeting specific concerns.

Crosslinked HA settles in the application site and can last months before being reabsorbed by the skin. Opt for this type of HA if you want to treat specific concerns and achieve long-lasting effects.


Non-crosslinked HA provides an overall moisturizing and plumping effect across the entire face. It is more subtle than its crosslinked counterpart, and its effects are more akin to what would happen if your skin suddenly produced great amounts of HA. It boosts overall skin radiance and smooths the skin, but it does not erase deep wrinkles or folds, nor treats specific concerns as a dermal filler would. Choose this type of HA when you want a rejuvenating and firming effect throughout the entire face. The effects last about a month.

To sum up, intradermal hyaluronic acid stands out as the leading active ingredient of this era. It visibly enhances skin texture and appearance while offering excellent skin tolerance and no adverse effects.

The outcomes are both natural and reversible. We invite you to explore INNOAESTHETICS’ new line of hyaluronic acid-based solutions and discover the wonders they can do for your skin.

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