Clinically evaluated protocol for improving skin barrier function in
Dry and Very Dry Skin
Dry skin and xerosis cutis are highly prevalent conditions
characterized by impaired skin barrier function, reduced stratum
corneum hydration, and increased transepidermal water loss (TEWL).
While frequently affecting the face, xerosis commonly involves other
areas such as the neckline, hands, and legs, significantly impacting
skin comfort and quality.
The INNOAESTHETICS Xeroskin protocol has been specifically designed
to restore barrier function, rebalance the hydrolipidic mantle, and
improve the skin’s ability to retain water, addressing xerosis at its
origin rather than masking symptoms.
Clinical and Biological
Features of Xerosis
Clinically, xerotic skin presents with roughness, scaling, reduced
elasticity, impaired skin comfort, sensations of tightness or
irritation, and increased sensitivity to environmental factors,
reflecting a progressive loss of barrier integrity and hydration
capacity.
From a Biological Standpoint, Xerosis Is Primarily Driven By:
Depletion of epidermal lipids, particularly ceramides
Reduced levels and altered composition of Natural Moisturizing
Factor (NMF)
Increased transepidermal water loss (TEWL)
Structural alterations of the stratum corneum and impaired
corneocyte cohesion
These mechanisms compromise the skin’s ability to retain water and
protect against external aggressors, perpetuating a cycle of dryness,
barrier damage, and reduced skin resilience.
Effective management therefore requires an integrated medical
approach addressing these underlying mechanisms through controlled
exfoliation, intensive rehydration, barrier repair, and long-term
maintenance of skin homeostasis.
Xeroskin Protocol
The Xeroskin program combines professional in-office treatment with
continuous home-care maintenance, two complementary and inseparable
phases. It can be applied to both facial and body areas affected by
xerosis.
1 Month
Professional phase
The Xeroskin Medical Protocol
Standard Treatment
4 sessions at 7-day intervals alternating peel and transdermal
treatment.
1st Session
1 week
2nd Session
1 week
3rd Session
1 week
4th Session
Intensive Protocol
4 sessions at 7-day intervals combining peel and transdermal
treatment in the same session.
1st Session
1 week
+
2nd Session
1 week
+
3rd Session
1 week
+
4th Session
+
3 Months
Home phase
Home-Care Maintenance
Long-term results require continuous home care to prevent relapse.
Recommended use: before, during, and after the in-office protocol.
Day Routine
+
INNO DERMA® Xeroskin Day Cream:
Hydration, comfort, and protection.
INNO DERMA® Keratoderm:
Supports desquamation and skin flexibility.
Night Routine
+
INNO DERMA® Xeroskin Night Cream:
Barrier repair with ceramides and NMF agents.
INNO DERMA® Keratoderm:
Supports desquamation and skin flexibility.
Clinically Proven Results
Representative images showing improvement in skin surface structure and hydration.
Before
After
Instrumentally Measured
Key Clinical Results
−23.3%
Mean Reduction in TEWL
Up to −51.8%
Changes in TEWL (% change)
% Change from Baseline
0−5−10−15−20−25
0.0%
−12.0%
−23.3%
BaselineAfter 2 monthsAfter 3 months
+17.2%
Mean Increase in Skin Elasticity
Up to +56%
Changes in Skin Elasticity (% change)
% Change from Baseline
20151050
0.0%
6.9%
17.2%
BaselineAfter 2 monthsAfter 3 months
Request information
Bring XEROSKIN to your practice
Discover an integrated in-clinic and home-care protocol for dry and very dry skin.
Complete the form to learn more about its professional application.
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